Abstract

Oxyntomodulin is a proglucagon-derived gut hormone that reduces food intake and body weight, thus represents a potential therapy for obesity. We synthesized and crystallized oxyntomodulin. The crystal diffracts x-ray to 2.4 Å resolution and belongs to space group P213 with unit-cell parameters a=b=c= 48.44 Å , α=β=γ=90°. Preliminary analysis indicates a trimer packing in one asymmetric unit.

Keywords: Oxyntomodulin, glucagon, GLP-1, diabetes, obesity, crystallization, synthesis