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Protein & Peptide Letters

Author(s): Jian-Xing Xu, Min Li and Ao-Jin Wang

DOI: 10.2174/092986608783489490

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Redox State of Cytochrome c Regulates Cellular ROS and Caspase Cascade in Permeablized Cell Model

Page: [200 - 205] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H2O2 generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.

Keywords: Redox state, cytochrome c, apoptosis, caspase