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Letters in Organic Chemistry

Author(s): Li-Wen Xu, Lei Yang, Wei Sun and Chun-Gu Xia

DOI: 10.2174/157017808783330270

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Zr(OTf)4-Catalyzed Direct Three-Component Mannich-Type Reaction of Carbamates: An Efficient One-Step Synthesis of N-Protected β- Aryl-β -Amino Ketones

Page: [34 - 37] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

Carbamates were reacted in one pot with aromatic aldehyde and ketones at ambient temperature in the presence of catalytic amount of Zr(OTf)4 to furnish the corresponding N-protected β-amino-β-aryl ketones in good yields.

Keywords: Aza-Michael reaction, Mannich reaction, Zirconium, one pot, carbamate, amino ketone