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Letters in Organic Chemistry

Author(s): Shengdong Zhu, Yuanxin Wu, Ziniu Yu, Xizhou Shen, Chengmiao Xu, Jun Yao, Hong Huang and Shiwei Jin

DOI: 10.2174/157017808783330126

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One-Pot Synthesis of Norfloxacin Ethyl Ester from 3-Chloro-4- Fluoroaniline in Ionic Liquid

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Abstract

Norfloxacin ethyl ester was prepared from 3-chloro-4-fluoroaniline in ionic liquid in a one-pot procedure by condensation with EMME [ethoxymethylenemalonic diethyl ester], cyclization, ethylation and condensation with anhydrous piperazine. After its hydrolysis, norfloxacin was obtained with an overall yield of 72.7%.

Keywords: Synthesis, norfloxacin ethyl ester, ionic liquid