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Letters in Organic Chemistry

Author(s): Fusheng Zhou, Jianbin Zheng, Xiaochun Dong, Zhiwen Zhang, Lingling Zhao, Xianyi Sha, Lin Li and Ren Wen

DOI: 10.2174/157017807782795484

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Synthesis and Antitumor Activities of 3-Substituted 1-(5-formylfurfuryl)indolin-2-one Derivatives

Page: [601 - 605] Pages: 5

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Abstract

Forty-two 3-substituted 1-(5-formylfurfuryl)indolin-2-ones were synthesized and most of these compounds exhibited potent inhibitory activities against P. oryzae (MIC = 0.78-25 μg/mL) and human intestinal Caco-2 cells (IC50 = 0.19-9.42 μM). Eight compounds selected for further screening also showed inhibitory activities (IC50 = 1.84-10.32 μM) against human lung adenocarcinoma cells (SPC-A1).

Keywords: 3-Substituted 1-(5-formylfurfuryl)indolin-2-ones, antitumor activity, antifungal activity, Pyricoraria oryzae, Caco-2 cells, SPC-A1