Abstract

Five analogues of neurotensin(NT:Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) were prepared by the solid-phase method and their comparative anorectic effects on food intake in rats were examined. Among them, [Phe(NO2)3,11]-NT and [Phe(4F)3,11]-NT showed stronger anorectic activity than that of the parent peptide but [Tyr(Me)3,11]-NT was less active than the parent peptide. On the contrary, the other two analogues, [Sar7,10]-NT and [beta Ala7,10]-NT had no anorectic activity.

Keywords: NEUROTENSIN (NT) ANALOGUES, anorectic activity, Neurotensin (NT)