Mini-Reviews in Medicinal Chemistry

Author(s): Naoki Asano, Atsushi Kato and Alison A. Watson

DOI: 10.2174/1389557013407052

DownloadDownload PDF Flyer Cite As
Therapeutic Applications of Sugar-Mimicking Glycosidase Inhibitors

Page: [145 - 154] Pages: 10

  • * (Excluding Mailing and Handling)

Abstract

Sugar-mimicking alkaloids inhibit the glycosidases involved in a wide range of important biological processes, principally owing to their structural resemblance to the sugar moiety of the natural substrate. The possibility of modifying and blocking these processes by using such inhibitors for therapeutic applications has attracted a lot of attention.

Keywords: Glycosidase Inhibitors, glycosidases, Castanospermine, Castanospermum australe, glucosidase inhibitors, Casuarina equisetifolia, Actinoplanes, antidiabetic agents, MANNOSIDASE INHIBITORS