Author(s): Ya-Jun Zheng, Yong Tao, Wei Zhang and Douglas B. Jordan
Page: [407 - 412] Pages: 6
* (Excluding Mailing and Handling)
Aldose reductase (AR) was cloned from the fungal pathogen, Magnaporthe grisea, expressed in Escherichia coli and purified to homogeneity. An experimental fungicide inhibits the M. grisea AR uncompetitively with respect to its aldehyde substrate with a Ki of 130 nM, the potency suggesting that AR is a biochemical target of the fungicide. The M. grisea AR has a high kcat and large differences in substrate specificities.
Keywords: fungal ALDOSE REDUCTASE, Magnaporthe grisea
Download PDF Flyer