Abstract

alpha2-Adrenergic receptor agonists are analgesic agents, and the alpha2-adrenergic agonist clonidine has been used in clinical studies for regional analgesia after intrathecal administration. We review here recent developments concerning the structure activity relationships of a new class of potent alpha2-adrenergic agonists and their use as analgesic agents. The effect of structure upon cardiovascular side effects is also monitored, such as the prolongation of the QT portion of the cardiac action potential.

Keywords: Adrenergic Receptor, Agonists as Analgesics, Imidazoles and Imidazolines, Adrenoceptor Agonists, Catecholamines, Oxazolines