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Protein & Peptide Letters

Author(s): S. C. Bourguignon, F. S. Paes, E. B. Calheiros, M. Juliano, A. S. Aguiar, A. R. Melgarejo and S. Giovanni-De-Simone

DOI: 10.2174/0929866013409689

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Bothrops Moojeni Venom Peptides Containing Bradykinin Potentiating Peptides Sequences

Page: [21 - 26] Pages: 6

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Abstract

Eight peptides were isolated from Bothrops moojeni venom by filtration followed by HPLC. MALDI mass spectroscopy and Edman degradation determined the purity, Mr and sequence of the peptides, respectively. Three (BmP7, BmP8 and BmvP11) of them were homologues with the biologically active B. jararaca bradykinin potentiating peptides while the other with peptides or protein from different sources.

Keywords: Bothrops moojeni, BRADYKININ, algesic hypotensive substance, Kininogenases, angiotensin I to II, angiotensin convertase, antihypertensive drugs, bradykinin potentiating peptides (BPPs)