Abstract

The secondary structure peptidomimetic approach is a rational way to develop novel nonpeptide pharmaceutical agents based upon biologically significant proteinaceous leads. A part of this approach elaborated in this laboratory over the past ten years is reviewed along with the recent developments in this field.

Keywords: secondary structure mimetics, peptidomimetic approach, proteinaceous leads, tetrapeptide units, privileged template, reverseturn mimetics, solid phase synthesis