Abstract

Active and passive immunization against fibrillar β-amyloid of various mice models of Alzheimers disease leads to the disaggregation and inhibition of plaque formation. Preliminary results showing improved behaviour and memory function obtained after administration of anti-β-amyloid vaccines to transgenic mice encourage these and related approaches for testing in the treatment and prevention of Alzheimers disease.

Keywords: Alzheimers Disease, EFRH-phage, Poly-L-lysine