Author(s): A. Dimoglo, E. Sim, N. Shvets and V. Ahsen
Page: [281 - 294] Pages: 14
* (Excluding Mailing and Handling)
A large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.
Keywords: cox-2, nsaids, structure-activity relationships (sar)
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