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Protein & Peptide Letters

Author(s): Pasquale Palladino, Carlo Pedone, Raffaele Ragone, Filomena Rossi, Michele Saviano and Ettore Benedetti

DOI: 10.2174/0929866033479022

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A Simplified Model Of The Binding Interaction Between Stromal Cell-Derived Factor-1 Chemokine And Cxc Chemokine Receptor 4

Page: [133 - 138] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4{29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4{29-39}.

Keywords: Stromal, Factor-1, CXCR4, peptide, chemokine