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Protein & Peptide Letters

Author(s): Zhi-Bo Wang, Min Li, Yungang Zhao and Jian-Xing Xu

DOI: 10.2174/0929866033479013

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Cytochrome C is a Hydrogen Peroxide Scavenger in Mitochondria

Page: [247 - 253] Pages: 7

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Abstract

The ability of succinate-cytochrome c reductase (SCR) reduced cytochrome c to scavenge H2O2 was investigated. H2O2, whether added or produced by SCR, was efficiently removed when cytochrome c was reduced by SCR. On the other hand, ferrocytochrome c underwent re-oxidization when H2O2 was added. Thus, these results indicate that cytochrome c reduced by succinate-cytochrome c reductase has the ability to regulate H2O2 in mitochondria.

Keywords: cytochrome, hydrogen peroxide, mitochondria, succinate-cytochrome c reductase