Abstract

Atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) was first introduced in 1999. In the last few years, there has been a rapid growth in publications describing the development and application of APMALDI to the mass spectrometric analysis of peptides, polymers and oligosaccharides. This short review discusses recent advances in AP-MALDI, focusing on the analysis of biomolecules and the relative performance of MALDI at atmospheric pressure and in vacuo.

Keywords: Atmospheric pressure, MALDI, Mass spectrometry