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Mini-Reviews in Medicinal Chemistry

Author(s): I. Baglin, A.- C. Mitaine-Offer, M. Nour, K. Tan, C. Cave and M.- A. Lacaille-Dubois

DOI: 10.2174/1389557033487917

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A Review of Natural and Modified Betulinic, Ursolic and Echinocystic Acid Derivatives as Potential Antitumor and Anti-HIV Agents

Page: [525 - 539] Pages: 15

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Abstract

The aim of this review is to update current knownledge on the betulinic, ursolic and echinocystic acids and their natural and semisynthetic analogs, focussing on their cytotoxic and anti-HIV activities. Then, the last results of the authors team on unusual semisynthetic derivatives of these triterpenoids will be presented in order to establish structure / activity relationships.

Keywords: betulinic, ursolic, echinocystic acid, antitumor, anti-hiv agents, anti-hiv activities