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Letters in Organic Chemistry

Author(s): E. Perez, J. Saez, S. Blair, X. Franck and B. Figadere

DOI: 10.2174/1570178043488743

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Isoquinoline Alkaloids from Duguetia Vallicola Stem Bark with Antiplasmodial Activity

Page: [102 - 104] Pages: 3

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Abstract

Duguevalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids, cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), were isolated and characterized from Duguetia vallicola stems. Structural elucidation of these compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4) exhibited antiplasmodial activity against Plasmodium falciparum.

Keywords: isoquinoline alkaloids, duguetia vallicola, annonaceae, antiplasmodial