Letters in Organic Chemistry

Author(s): Nigel J. Parr, Stephen C. McKeown, Mika K. Lindvall, Olivier E. Lorthioir, Miles S. Congreve and Stephen P. Watson

DOI: 10.2174/1570178043488653

The Application of Quantitative Analytical Constructs for Chemistry Optimization, Monomer Rehearsal and Reactivity Prediction in Solid Phase Library Synthesis

Page: [87 - 92] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

The use of quantitative dual linker analytical constructs for the high-throughput generation of solid phase reaction data is described. This methodology can be applied to chemistry optimization, monomer rehearsal and monomer reactivity prediction as a tool to aid the production of solid phase compound libraries.

Keywords: analytical methods, combinatorial chemistry, mass spectrometry, solid-phase synthesis