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Letters in Organic Chemistry

Author(s): Kamil Kuca, Jiri Cabal, Jiri Patocka and Jiri Kassa

DOI: 10.2174/1570178043488761

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Synthesis of Bisquaternary Symmetric - X,δ-Bis(2-Hydroxyiminomethylpyridinium) Alkane Dibromides and Their Reactivation of Cyclosarin-Inhibited Acetylcholinesterase

Page: [84 - 86] Pages: 3

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Abstract

Preparations of the symmetric bisquaternary oximes - 1,4-bis(2-hydroxyiminomethypyridinium) butane dibromide and 1,3-bis(2-hydroxyiminomethypyridinium)propane dibromide, and their abilities to reactivate cyclosarin-inhibited acetylcholinesterase are described. Common reactivator (pralidoxime) was used as a standard for comparison of the reactivation efficacy. The first oxime seems to be very good reactivator of cyclosarin-inhibited acetylcholinesterase.

Keywords: oximes, reactivation, acetylcholinesterase, cyclosarin