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Letters in Organic Chemistry

Author(s): E. Kerouredan, M. Prakesch, D. Gree and R. Gree

DOI: 10.2174/1570178043488662

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Total Synthesis of the 13,13 Difluoro Analog of the 13 HODE

Page: [78 - 80] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

The first total synthesis of the 13,13 difluoro analog of 13 HODE, via the novel fluorinated synthons (5) and (2), is reported. The key advantages of using a propargylic route for the introduction of the gem difluoro moiety are highlighted below.

Keywords: fluorine, dast, 13 hode, lipids