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Letters in Organic Chemistry

Author(s): Hiroki Hamada, Kohji Ishihara, Nobuyoshi Nakajima, Hatsuyuki Hamada, Howard J. Williams and Alastair I. Scott

DOI: 10.2174/1570178043488455

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Enzymatic Oxidation of 1,4- and 1,8-Cineole using Plant Cultured Cells of Catharanthus Roseus

Page: [171 - 172] Pages: 2

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Abstract

Oxidases present in plant cultured cells of Catharanthus roseus can hydroxylate saturated centers of natural products without double bond activation. When starting materials were 1,8- or 1,4-cineole, secondary and tertiary alcohols were produced and identified using NMR and mass spectroscopy. Our results indicate that hydroxylation position and stereochemistry are determined by the biotransformation organism.

Keywords: 1,8-cineole, catharanthus roseus, biotransformation organism