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Letters in Organic Chemistry

Author(s): Tomohisa Moriguchi, Kazuhisa Okada, Kohji Seio and Mitsuo Sekine

DOI: 10.2174/1570178043488482

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Synthesis and Stability of 1-Phenylethenyl Phosphate Derivatives and their Phosphoryl Transfer Activity

Page: [140 - 144] Pages: 5

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Abstract

1-Phenylethenyl phosphate derivatives of the monoester type were synthesized via the Perkow reaction. Among them, 2-(2,4-difluorophenyl)ethenyl phosphate was found to be obtained as a pure salt. It turned out that this compound and 2-phenylethenyl phosphate can transfer their phosphoryl groups to AMP in pyridine at elevated temperatures to give ADP.

Keywords: enol phosphate, phosphoryl transfer, phosphorylation, perkow reaction