Author(s): Holger Stark, Markus Kathmann, Eberhard Schlicker, Walter Schunack, Birgit Schlegel and Wolfgang Sippl
Page: [965 - 977] Pages: 13
* (Excluding Mailing and Handling)
The first antagonists known for the histamine H3 receptor were mono-substituted imidazolecontaining compounds like thioperamide. Meanwhile numerous novel leads have been developed possessing improved affinities, selectivities, specificities, and pharmacokinetic properties. Scope and limitations of this promising class are discussed concerning their structure-activity relationships as well as pharmacological and potential therapeutic aspects.
Keywords: cipralisant, ciproxifan, clobenpropit, h3 receptor, imidazole, sch 79687, radioligand, thioperamide
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