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Letters in Organic Chemistry

Author(s): Yuichi Kobayashi, Yong-Gang Wang and Hukum P. Acharya

DOI: 10.2174/1570178043400424

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Total Syntheses of Macrosphelides C, F, G and H

Page: [297 - 307] Pages: 11

  • * (Excluding Mailing and Handling)

Abstract

The title macrosphelides were synthesized by using two-step conversion of furans into γ-oxo-α,β- unsaturated carboxylic acids as a key step. In the case of macrosphelide H, AcCH2 group at C(3) was constructed from CH2=CHCH2 by Wacker oxidation under modified conditions.

Keywords: macrosphelide, asymmetric synthesis, wacker oxidation, furan, furan oxidation