Author(s): Xavier de Leval, Fabien Julemont, Valerie Benoit, Michel Frederich, Bernard Pirotte and Jean-Michel Dogne
Page: [597 - 601] Pages: 5
* (Excluding Mailing and Handling)
The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.
Keywords: cox-2 inhibitors, cox-2 selectivity, pre-clinical data
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