Author(s): Larisa V. Kordyukova, Aleksander L. Ksenofontov, Marina V. Serebryakova, Tatyana V. Ovchinnikova, Natalija V. Fedorova, Valeria T. Ivanova and Ludmila A. Baratova
Page: [385 - 391] Pages: 7
* (Excluding Mailing and Handling)
MALDI-TOF MS and N-terminal amino acid sequencing allowed us to identify several fragments of the C-terminal peptide of Influenza A hemagglutinin (HA) containing transmembrane domains (TMD). These fragments were detected in the organic phase of chloroform-methanol extracts from bromelain-treated virus particles. Heterogeneous fatty acylation of the C-terminus was revealed. Tritium bombardment technique might open an opportunity for 3D structural investigation of the HA TMD in situ.
Keywords: influenza a virus, hemagglutinin, fatty acylation, transmembrane domain
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