Author(s): Nylane M.N. Alencar, Ana M.S. Assreuy, David N. Criddle, Emmanuel P. Souza, Pedro M.G. Soares, Alexandre Havt, Karoline S. Aragao, Daniel P. Bezerra, Ronaldo A. Ribeiro and Benildo S. Cavada
Page: [195 - 200] Pages: 6
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A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400μg / paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.
Keywords: paw edema,, leukocyte infiltration,, Vatairea macrocarpa lectin.
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