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Protein & Peptide Letters

Author(s): Emer S. Ferro, Flavia R. Carreno, Camila Goni, Paula A.G. Garrido, Alessander O. Guimaraes, Leandro M. Castro, Vitor Oliveira, Mauricio C. Araujo, Vanessa Rioli, Marcelo D. Gomes, Jose Domingues Fontenele-Neto and Stephen Hyslop

DOI: 10.2174/0929866043406706

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The Intracellular Distribution and Secretion of Endopeptidases 24.15 415 (Ec 3.4.24.15) and 24.16 (Ec 3.4.24.16)

Page: [415 - 421] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Endopeptidase 24.15 (EC 3.4.24.15; EP24.15) and endopeptidase 24.16 (EC 3.4.24.16; EP24.16) are enzymes involved in general peptide metabolism in mammalian cells and tissues. This review will focus on morphological and biochemical aspects related to the subcellular distribution and secretion of these homologous enzymes in the central nervous system. These are important issues for a better understanding of the functions of EP24.15 and EP24.16 within neuroendocrine systems.

Keywords: endopeptidase, exocytosis, neurolysin, peptide metabolism, thimet-oligopeptidase, unconventional, secretion, fusion pore