Author(s): Yuhui Huang, Ruiyang Tian, Wei Hu, Xiangfu Wu, Shengli Yang and Yi Gong
Page: [49 - 55] Pages: 7
* (Excluding Mailing and Handling)
A fusion protein (scu-PA:AV) was expressed in the baculovirus expression system and secreted from Sf9 cells lead by signal peptides, 2mel and 3egt. The scu-PA:AV displays both the urokinase activity and membrane binding activity of its parental components. Our work indicated that it is possible to be developed as a thrombus-targeting drug.
Keywords: protein expression, signal peptide, baculovirus-insect cell system, annexin v, low molecular weight urokinase
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