Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery

E.   ter   Haar; W.   P.   Walters; S.      Pazhanisamy; P.      Taslimi; A.   C.   Pierce; G.   W.   Bemis; F.   G.   Salituro; S.   L.   Harbeson

Mini-Reviews in Medicinal Chemistry

Author(s): E. ter Haar, W. P. Walters, S. Pazhanisamy, P. Taslimi, A. C. Pierce, G. W. Bemis, F. G. Salituro and S. L. Harbeson

DOI: 10.2174/1389557043487367

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Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery

Page: [235 - 253] Pages: 19

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Abstract

Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPKfamily will be discussed.

Keywords: chemogenomics, kinases, structure-based drug design

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