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Letters in Organic Chemistry

Author(s): P. Gaertner, C. Schuster and M. Knollmueller

DOI: 10.2174/1570178043400901

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Chiral Linker 1. A Novel Chiral Auxiliary Derived from m-Hydrobenzoin as Enantiomerically Pure Linker for Solid Phase Organic Chemistry

Page: [249 - 253] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

The synthesis and utility of a novel, m-hydrobenzoin derived chiral auxiliary in stereoselective α- alkylation reactions using convenient solution chemistry as well as the attachment of an analogous system onto a solid support and its application as a dual chiral auxiliary and linker is described.

Keywords: polymer support, chiral auxiliary, linker, enolate, alkylation, hydrobenzoin