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Letters in Organic Chemistry

Author(s): Jesus Vazquez, Miriam Royo and Fernando Albericio

DOI: 10.2174/1570178043400992

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Re-Evaluation of a Solid-Phase Hydantoin Synthesis

Page: [224 - 226] Pages: 3

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Abstract

Solid-phase methods for the preparation of hydantoins are reviewed. Furthermore, an optimized method based on the concourse of 1,1-carbonyldiimidazole allows the preparation of hydantoins without loss of chiral integrity.

Keywords: amino acid, combinatorial chemistry, cyclization, libraries, solid support