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Letters in Organic Chemistry

Author(s): G. Broggini, I. De Marchi, M. Martinelli, G. Paladino and A. Penoni

DOI: 10.2174/1570178043400956

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Intramolecular Azide Cycloaddition enroute to the New Pyrrolo[2,1-c][1,2,3] triazolo[1,5-a][1,4]benzodiazepine Skeleton

Page: [221 - 223] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

The unknown pyrrolo[2,1-c][1,2,3]triazolo[1,5-a][1,4]benzodiazepin-8-one ring system has been synthesised starting from the N-Boc-L-proline methyl ester. The totally diastereoselective intramolecular 1,3- dipolar cycloaddition of the azide 9 constitutes the key step of the synthetic sequence.

Keywords: 1,4-benzodiazepin-5-ones, pyrrolo[2,1-c][1,4]benzodiazepin-5-ones, intramolecular cycloadditions, azides, diastereoselective reactions