Author(s): P. G. Cozzi and M. Locatelli
Page: [208 - 211] Pages: 4
* (Excluding Mailing and Handling)
A small library of aryl and dialkyl 3-hydroxy thiophene 2-oxazolines was simply prepared by direct and selective metalation of 4-tertbutyl-2-(thiophene-2-yl)-4,5-dihidrooxazole and its successive reaction with aromatic and aliphatic ketones. The ligand 7h was able to promote the addition of Me2Zn to aromatic aldehydes with good enantioselectivity (up to 92 % ee).
Keywords: me2zn, asymmetric catalysis, thiophene, aldehydes, ligand library
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