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Letters in Organic Chemistry

Author(s): Fahim Ahmed, Yeyu Cao and William A. Donaldson

DOI: 10.2174/1570178053765366

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Development of Organoiron Methodology for the C8-C16 Dienylamine Segment of the Streptogramin Antibiotics

Page: [222 - 225] Pages: 4

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Abstract

Methodology for preparation of the C8-C16 dienylamine segment of the streptogramin antibiotics is based on a diastereoselective nitrile oxide-olefin cycloaddition to a (triene)iron complex. The Fe(CO)3 adjunct also serves as a protecting group for the subsequent reductive hydrolysis of the isoxazoline ring.

Keywords: streptogramin antibiotics, (diene)iron complexes, cyclocondensation