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Protein & Peptide Letters

Author(s): Qian-Yu Zhao, Qiang Chen, Yun Feng, Xin Lin and Rui Wang

DOI: 10.2174/0929866053765743

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[TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings

Page: [323 - 326] Pages: 4

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Abstract

[Tic4]EM1 and [Tic4]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that [Tic4]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor.

Keywords: tic, endomorphins, opioid, vasorelaxant response, rat aorta rings