Abstract

Combinatorial and high throughput methods have recently been applied to chemical reaction development as it greatly increases the reactivity "space" available to the chemist. Recent focus has been the development of detection methods, particularly those directed towards enantioselectivity. Progress in this area has been reviewed with particular emphasis placed on recent enantioselective methods.

Keywords: high throughput screening, combinatorial chemistry, parallel synthesis, reaction screening, asymmetric reaction screening, enantioselective reaction screening