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Letters in Organic Chemistry

Author(s): Armandodoriano Bianco, Francesco Bonadies, Raffaella Napolitano and Giancarlo Ortaggi

DOI: 10.2174/1570178053399921

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A Simple Approach to DC-Cholesterol, its Analogues and Vitamin D-Based Cationic Lipids for Gene Therapy

Page: [79 - 82] Pages: 4

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Abstract

An improved synthesis of DC-Cholesterol, its analogues and Vitamin D-based lipids for the preparation of liposomes in gene therapy, is described. This synthetic strategy affords significative increase in the yields of DC-Cholesterol and its analogs.

Keywords: cationic lipids, gene therapy, dc-cholesterol, modified curtius reaction, dc-vitamin d-based cationic lipids