Abstract

Allosteric modulators allow for the fine-tuning of receptor responses to endogenous neurotransmitters and exogenous therapeutic agents. Different types of allosteric modulation of dopamine receptors are discussed as well as the significance of such modulation in the control of normal biological processes and in the treatment of disease.

Keywords: conformational change, regulation, modulate, plateau, catecholamine, biogenic amine, g protein-coupled receptor (gpcr), metal