Abstract

Bronchiolitis obliterans and organizing pneumonia (BOOP) represent complex clinical syndromes expressing a similar morphologic pattern, which are observed in a variety of lung diseases. In this view, the Authors report on the clinical and diagnostic profile, radiological features, laboratory and histopathological findings, and management issues of these broad-spectrum pulmonary disorders. Idiopathic forms, infectious disease-associated features, complications of solid organ transplant recipients and bone marrow recipients, collagen vascular- and bowel inflammatory-related forms, the role of drugs and that of irritating and toxic inhalants, and more infrequent ethiologies (which are able to support a bronchiolitis obliterans-organizing pneumonia and related conditions), all these items are thoroughly discussed on the ground of our own experience in this field, and an updated literature review.

Keywords: bronchiolitis obliterans, organizing pneumonia, clinical and diagnostic features, classification, management, outcome