Letters in Organic Chemistry

Author(s): P. Merino, S. Franco, P. Jimenez, T. Tejero and M. A. Chiacchio

DOI: 10.2174/1570178054038803

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Effect of Additional Chiral Ligands in Catalytic Enantioselective Addition of Ketene Silyl Acetals to Nitrones

Page: [302 - 305] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

The enantioselectivity of the titanium (IV)-BINOL catalyzed asymmetric Mannich-type reactions of nitrones can be enhanced by using additional chiral ligands. The best results are obtained with diols derived from D-mannitol.

Keywords: nitrones, hydroxylamines, aminoacids, mannich reaction