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Letters in Organic Chemistry

Author(s): Luis M. De Leon-Rodriguez, Zoltan Kovacs and Alan D. Sherry

DOI: 10.2174/1570178053202838

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Chemistry for DOTA Peptide Labeling at Phenylalanine Residues: On the Road to Preparing Peptide Ligand Tagged Libraries

Page: [160 - 164] Pages: 5

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Abstract

Different synthetic strategies to control the position of DOTA in phenylalanine residues within a peptide sequence were studied and compared. The results showed that use of DOTA pre-labeled amino acids stands as the most promising procedure for the synthesis of peptide ligand tagged libraries by solid phase peptide synthesis.

Keywords: peptide, dota, tag, phenylalanine, mri