Author(s): Arnault de Filippis, Domingo Gomez Pardo and Janine Cossy
Page: [136 - 138] Pages: 3
* (Excluding Mailing and Handling)
A very short and efficient synthesis of preclamol is described. The key step is the palladiumcatalysed arylation of the zinc enolate of N-propyl-2-piperidinone.
Keywords: preclamol, arylations, lactams, palladium, zinc, coupling reaction
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