Abstract

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

Keywords: 1,2,4,5-tetraoxacycloalkanes, 1,2,5,6-tetraoxacycloalkanes, 1,2,6,7-tetraoxaspiro[7.11]nonadecane, antimalarial activity, medium-sized cyclic peroxides, cyclization methods, p. falciparum, p. berghei