Abstract

The Michael addition of ketone-derived enamines to γ-fluoro-α-nitroalkenes provides in moderate to good isolated yields the corresponding β-fluoroalkyl γ-nitroketones, which can be reduced to β-fluoroalkyl γ- nitroalcohols.

Keywords: nitroalkenes, fluorinated building blocks, michael addition, diels-alder, dipolar reactions, (nitroaldol) reaction, tbaf, mukaiyama-like conditions