Mini-Reviews in Medicinal Chemistry

Author(s): Jean-Yves Reginster, Florence Heraud, Brigitte Zegels and Olivier Bruyere

DOI: 10.2174/138955707782110088

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Symptom and Structure Modifying Properties of Chondroitin Sulfate in Osteoarthritis

Page: [1051 - 1061] Pages: 11

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Abstract

Chondroitin sulfate (CS) is a complex carbohydrate polymer with variable sulfation which impacts function. CS exhibits a wide range of biological activities. Many experimental and clinical data are available, affirming that CS represents an effective and safe symptomatic treatment of osteoarthritis (OA) with delayed and sustained effects.

Keywords: Chondroitin sulfate, sulfation patterns, cartilage, glycosaminoglycans, osteoarthritis, SYSADOAs