One-Pot Synthesis of 1,3-Thiazolidin-4-Ones Derivatives from 2-Amino-1,3,4-Thiadiazole

Wilson      Cunico; Claudia   R. B.   Gomes; Maria de Lourdes   G.   Ferreira; Liliane   R.   Capri; Margareth   R. L.   Santos; Paula   M.   Sa; Nubia      Boechat; Monica   M.   Bastos; Lindalva   C.   Maciel; Lucia   M. U.   Mayer

Letters in Organic Chemistry

Author(s): Wilson Cunico, Claudia R. B. Gomes, Maria de Lourdes G. Ferreira, Liliane R. Capri, Margareth R. L. Santos, Paula M. Sa, Nubia Boechat, Monica M. Bastos, Lindalva C. Maciel and Lucia M. U. Mayer

DOI: 10.2174/157017807782006245

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One-Pot Synthesis of 1,3-Thiazolidin-4-Ones Derivatives from 2-Amino-1,3,4-Thiadiazole

Page: [505 - 508] Pages: 4

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Abstract

Several 1,3-thiazolidin-4-ones were synthesized by cyclocondensation reaction of 2-amino-1,3,4-thiadiazole, mercaptoacetic acid and various arenealdehydes in moderate to good yields. These compounds were characterized by 1H, 13C and 19F NMR. The antimalarial activity of thiazolidinones was evaluated in vitro against Plasmodium falciparum clone but none of them showed activity at maximum concentration (50μg/ml) used.

Keywords: 4-thiazolidinone, heterocycles, cyclocondensation

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