Abstract

The one-step synthesis of a new series of protected 6-alkyl- and 6-aryl-2-acetylamino-4(3H)-pyrimidinones, where alkyl = CH3; aryl = Ph, 4-CH3Ph, 4-FPh, 4-ClPh, 4-BrPh and 4-OCH3Ph from the reaction of 4-methoxy-1,1,1- trichloroalk-3-en-2-ones with 1-acetylguanidine in acetonitrile as solvent is reported. The acetylamino group of 2- acetylamino-4(3H)-pyrimidinones has also been hydrolyzed under three different conditions to afford the corresponding free 2-aminopyrimidinones.

Keywords: Aminopyrimidines, pyrimidinones, deprotection, haloform reaction, ketones, heterocycles