Reductive Amination of Carbonyl Compounds with NaBH4-H3PW12O40 in THF and Under Solvent-Free Conditions

Heshmatollah      Alinezhad; Ehsan      Ardestani

Letters in Organic Chemistry

Author(s): Heshmatollah Alinezhad and Ehsan Ardestani

DOI: 10.2174/157017807782006254

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Reductive Amination of Carbonyl Compounds with NaBH4-H3PW12O40 in THF and Under Solvent-Free Conditions

Page: [473 - 477] Pages: 5

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Abstract

A simple, completely chemoselective, and convenient procedure for reductive amination of aldehydes and ketones using NaBH4 in the presence of H3PW12O40 in THF and under solvent-free conditions at ambient temperature is described.

Keywords: Reductive amination, H3PW12O40, NaBH4, solvent-free conditions

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